Icariin regulates miR-23a-3p-mediated osteogenic differentiation of BMSCs via BMP-2/Smad5/Runx2 and WNT/β-catenin pathways in osteonecrosis of the femoral head.
作者:
关键词
BAP, bone-specific alkaline phosphataseBMP-2, bone morphogenetic protein-2BMP-2/Smad5/Runx2 pathwayBMP-4, bone morphogenetic protein-4BMSCs, bone marrow-derived mesenchymal stem cellsCTX-1, C-terminal telopeptides of type I collagenDMEM, Dulbecco’s modified Eagle’s mediumDR, Digital RadiographyFBS, fetal bovine serumHE, Hematoxylin‐eosinIcariinLPS, lipopolysaccharideNTX-1, N-terminal telopeptides of type I collagenOC, osteocalcinONFH, osteonecrosis of the femoral headOsteonecrosis of the femoral headRT-PCR, Real time PCRSI, icariin-containing serumTRACP-5b, tartrate-resistant acid phosphatase 5bWNT/β-catenin pathwaymiR-23a-3p
DOI
10.1016/j.jsps.2021.10.009
PMID
35002378
发布时间
2022-01-11
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Saudi pharmaceutical journal
2021年29卷12期
1405-1415页
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