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Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy.

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第一作者： Chune,Yu

第一单位： Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 17, 3rd Section, Renmin South Road, Chengdu, 610041, Sichuan, China.

作者： Chune,Yu ^[1] ; Min,Zhang ^[1] ; Jinen,Song ^[1] ; Xiaobo,Zheng ^[1] ; Guangchao,Xu ^[2] ; Yu,Bao ^[1] ; Jiang,Lan ^[1] ; Dan,Luo ^[3] ; Jianping,Hu ^[4] ; Jingyi Jessica,Li ^[5] ; Hubing,Shi ^[6]

作者单位： Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 17, 3rd Section, Renmin South Road, Chengdu, 610041, Sichuan, China. ^[1] Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 17, 3rd Section, Renmin South Road, Chengdu, 610041, Sichuan, China.;Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China. ^[2] Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 17, 3rd Section, Renmin South Road, Chengdu, 610041, Sichuan, China.;Department of Immunology, School of Basic Medical Sciences, Chengdu medical College, Chengdu, 610500, Sichuan, China. ^[3] College of Pharmacy and Biological Engineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, 610106, China. ^[4] Department of Statistics, University of California, Los Angeles, CA, 90095-1554, USA. ^[5] Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 17, 3rd Section, Renmin South Road, Chengdu, 610041, Sichuan, China. shihb@scu.edu.cn. ^[6]

关键词 Integrin-Src-YAP1 axis MAPK Melanoma PI3K/mTOR Resistance Targeted therapy

DOI 10.1186/s43556-020-00013-0

PMID 35006410

发布时间 2022-01-12

基金项目

2016YFC0906000/National Key Research and Development Program of China 81773752/National Natural Science Foundation of China 81902793/National Natural Science Foundation of China 81803574/National Natural Science Foundation of China 31801143/National Natural Science Foundation of China 2017SZ00005/Key Program of the Science and Technology Bureau of Sichuan 2019M653430/China Postdoctoral Science Foundation 2018HXBH003/Post-Doctor Research Project, West China Hospital, Sichuan University

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Molecular biomedicine

2020年1卷1期

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Molecular biomedicine

2020年1卷1期

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Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy.

Molecular biomedicine

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Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy.

Molecular biomedicine

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Molecular biomedicine

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