首页> European journal of medicinal chemistry> Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo.

Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo.

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第一作者： Xiao,Wang

第一单位： Immunology Innovation Team, School of Medicine, Ningbo University, Ningbo, Zhejiang, 315211, China.

作者： Xiao,Wang ^[1] ; Hongda,Qiu ^[2] ; Na,Yang ^[3] ; Haoji,Xie ^[1] ; Weida,Liang ^[2] ; Jiayu,Lin ^[2] ; Haifeng,Zhu ^[2] ; Yuan,Zhou ^[4] ; Ning,Wang ^[5] ; Xinyi,Tan ^[1] ; Jiale,Zhou ^[1] ; Wei,Cui ^[1] ; Da,Teng ^[3] ; Jianhua,Wang ^[6] ; Hongze,Liang ^[7]

作者单位： Immunology Innovation Team, School of Medicine, Ningbo University, Ningbo, Zhejiang, 315211, China. ^[1] Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, China. ^[2] Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. ^[3] School of Medical Technology, Xuzhou Medical University, Xuzhou, 221004, China. ^[4] Institute of Drug Discovery Technology, Ningbo University, Ningbo, 315211, Zhejiang, China. ^[5] Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. Electronic address: wangjianhua@caas.cn. ^[6] Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, China. Electronic address: lianghongze@nbu.edu.cn. ^[7]

关键词 Antibacterial Antibiofilm Fascaplysin derivatives MRSA Marine drugs Mechanisms

医学主题词抗菌药(Anti-Bacterial Agents);生物膜(Biofilms);DNA(DNA);吲哚类(Indoles);耐甲氧西林金黄色葡萄球菌(Methicillin-Resistant Staphylococcus aureus);微生物敏感性试验(Microbial Sensitivity Tests)

DOI 10.1016/j.ejmech.2021.114099

PMID 35007859

发布时间 2022-02-15

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