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Efficacy of Front-Line Ibrutinib and Rituximab Combination and the Impact of Treatment Discontinuation in Unfit Patients with Chronic Lymphocytic Leukemia: Results of the Gimema LLC1114 Study.

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第一作者: Francesca Romana,Mauro
第一单位: Hematology, Department of Translational and Precision Medicine, Sapienza University, Via Benevento 6, 00161 Rome, Italy.
作者单位: Hematology, Department of Translational and Precision Medicine, Sapienza University, Via Benevento 6, 00161 Rome, Italy. [1] GIMEMA Foundation, 00187 Rome, Italy. [2] Department of Hematology, Pugliese Ciaccio Hospital, 88100 Catanzaro, Italy. [3] Hematology Department, Foundation IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan, 20100 Milan, Italy. [4] Hematology Division, Department of Medicine, University of Padua, 35128 Padua, Italy. [5] Institute of Hematology-Centro di Ricerca Emato-Oncologica (CREO), Department of Medicine, University of Perugia, 06129 Perugia, Italy. [6] Department of Hematology, SS. Antonio e Biagio e Cesare Arrigo Hospital and University of Eastern Piedmont, 15121 Alessandria, Italy. [7] Department of Hematology, Azienda Ospedaliera SS Arrigo e Biagio e Cesare Arrigo, 15121 Alessandria, Italy. [8] Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41126 Modena, Italy. [9] Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, AOU Maggiore della Carità, 28100 Novara, Italy. [10] Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, 10100 Torino, Italy. [11] Department of Hematology, Azienda Ospedaliera Bianchi Melacrino Morelli, 89124 Reggio Calabria, Italy. [12] Division of Hematology, Azienda Ospedaliera Papardo, 98158 Messina, Italy. [13] Hematology and Stem Cell Transplant Unit, "Vito Fazzi" Hospital, 73100 Lecce, Italy. [14] Hematology, Azienda Ospedaliera Arcispedale Santa Maria Nuova IRCCS, 42123 Reggio Emilia, Italy. [15] Department of Hematology, Università degli Studi di Perugia, A.O.S., 05100 Terni, Italy. [16] Department of Hematology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, 10100 Torino, Italy. [17] Hematology and Bone Marrow Transplant Center, Azienda Ospedaliera Universitaria di Parma, 43126 Parma, Italy. [18] Division of Hematology, Santa Maria delle Croci Hospital, 48121 Ravenna, Italy. [19] Istituto Scientifico Romagnoli per lo Studio e la Cura dei Tumori-IRST, 47014 Meldola, Italy. [20] A.O.U. S. Giovanni Battista A.O. Mauriziano-Umberto I, 10128 Torino, Italy. [21] IRCCS Azienda Ospedaliero-Universitaria di Bologna-Istituto di Ematologia "Seràgnoli" and Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, 40138 Bologna, Italy. [22] Hematology, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy. [23] Department of Oncology and Hematology, Infermi Hospital, 47923 Rimini, Italy. [24] Hematology Section, Cosenza Hospital, 87100 Cosenza, Italy. [25] Division of Haematology, Azienda Policlinico-OVE, 95123 Catania, Italy. [26] Fondazione Policlinico Universitario A Gemelli, IRCCS, 00168 Rome, Italy. [27] Division of Hematology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy. [28] U.O. Ematologia e Centro Trapianti di Midollo, Policlinico San Martino, 16132 Genova, Italy. [29] Hematology and Stem Cell Transplantation Unit, Ospedale A. Businco, ARNAS "G. Brotzu", 34121 Cagliari, Italy. [30] Hematology, Department of Translational and Precision Medicine, Sapienza University, Via Benevento 6, 00161 Rome, Italy.;GIMEMA Foundation, 00187 Rome, Italy. [31] Hematology Section, St. Anna University Hospital, 44121 Ferrara, Italy. [32]
DOI 10.3390/cancers14010207
PMID 35008372
发布时间 2022-01-14
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