A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.

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作者： Jonathan S,Katz ^[1] ; Jeffrey D,Rothstein ^[2] ; Merit E,Cudkowicz ^[3] ; Angela,Genge ^[4] ; Björn,Oskarsson ^[5] ; Avis B,Hains ^[6] ; Chen,Chen ^[6] ; Joshua,Galanter ^[6] ; Braydon L,Burgess ^[6] ; William,Cho ^[6] ; Geoffrey A,Kerchner ^[7] ; Felix L,Yeh ^[6] ; Arundhati Sengupta,Ghosh ^[6] ; Sravanthi,Cheeti ^[6] ; Logan,Brooks ^[6] ; Lee,Honigberg ^[6] ; Jessica A,Couch ^[6] ; Michael E,Rothenberg ^[6] ; Flavia,Brunstein ^[6] ; Khema R,Sharma ^[8] ; Leonard,van den Berg ^[9] ; James D,Berry ^[10] ; Jonathan D,Glass ^[11]

作者单位： Forbes Norris MDA/ALS Research Center, California Pacific Medical Center, San Francisco, California, USA. ^[1] Johns Hopkins Hospital, Baltimore, Maryland, USA. ^[2] Sean M. Healey and AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. ^[3] Montreal Neurological Institute & Hospital, Montreal, QC, Canada. ^[4] Mayo Clinic, Jacksonville, Florida, USA. ^[5] Genentech, Inc., South San Francisco, California, USA. ^[6] F. Hoffmann-La Roche, Ltd., Basel, Switzerland. ^[7] University of Miami Hospital (CRC), Miami, Florida, USA. ^[8] UMC Utrecht, Utrecht, The Netherlands. ^[9] Neurological Clinical Research Institute, Boston, Massachusetts, USA. ^[10] Emory University School of Medicine, Atlanta, Georgia, USA. ^[11]

主题词成年人(Adult);老年人(Aged);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);动物(Animals);剂量效应关系, 药物(Dose-Response Relationship, Drug);双盲法(Double-Blind Method);女(雌)性(Female);人类(Humans);MAP激酶激酶激酶类(MAP Kinase Kinase Kinases);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);中年人(Middle Aged);神经微丝蛋白质类(Neurofilament Proteins);蛋白激酶抑制剂(Protein Kinase Inhibitors)

DOI 10.1002/acn3.51491

PMID 35014217

发布时间 2022-03-16

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Annals of clinical and translational neurology

2022年9卷1期

50-66页

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A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.

Annals of clinical and translational neurology

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Annals of clinical and translational neurology

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A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.

Annals of clinical and translational neurology

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Annals of clinical and translational neurology

相关期刊

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