Mechanochemical Drug Conjugation via pH-Responsive Imine Linkage for Polyether Prodrug Micelles.

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作者： Sohee,Han ^[1] ; Joonhee,Lee ^[1] ; Eunkyeong,Jung ^[2] ; Suebin,Park ^[1] ; Aoi,Sagawa ^[3] ; Yuji,Shibasaki ^[3] ; Dongwon,Lee ^[2] ; Byeong-Su,Kim ^[1]

作者单位： Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea. ^[1] Department of Polymer Nano Science and Technology, Chonbuk National University, Jeonju 54896, Republic of Korea. ^[2] Department of Chemistry and Biological Sciences, Faculty of Science and Engineering, Iwate University, 4-3-5 Ueda, Morioka, Iwate 020-8551, Japan. ^[3]

关键词 anionic ring-opening polymerization imine mechanochemistry polymer?drug conjugates post-polymerization modification

主题词丙烯醛(Acrolein);动物(Animals);抗肿瘤药, 植物(Antineoplastic Agents, Phytogenic);生物相容性材料(Biocompatible Materials);细胞系(Cell Line);细胞存活(Cell Survival);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);醚类(Ethers);人类(Humans);氢离子浓度(Hydrogen-Ion Concentration);亚胺类(Imines);材料试验(Materials Testing);小鼠(Mice);微胶粒(Micelles);分子结构(Molecular Structure);粒子大小(Particle Size);聚合物(Polymers);药物前体(Prodrugs)

DOI 10.1021/acsabm.0c01437

PMID 35014365

发布时间 2022-03-28

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ACS applied bio materials

2021年4卷3期

2465-2474页

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Mechanochemical Drug Conjugation via pH-Responsive Imine Linkage for Polyether Prodrug Micelles.

ACS applied bio materials

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Mechanochemical Drug Conjugation via pH-Responsive Imine Linkage for Polyether Prodrug Micelles.

ACS applied bio materials

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