The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr/Ser(UCN) to optimise tRNA structure and mitochondrial translation.

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作者： Nicole,Kleiber ^[1] ; Nicolas,Lemus-Diaz ^[1] ; Carina,Stiller ^[2] ; Marleen,Heinrichs ^[3] ; Mandy Mong-Quyen,Mai ^[3] ; Philipp,Hackert ^[1] ; Ricarda,Richter-Dennerlein ^[3] ; Claudia,Höbartner ^[4] ; Katherine E,Bohnsack ^[2] ; Markus T,Bohnsack ^[5]

作者单位： Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany. ^[1] Institute of Organic Chemistry, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany. ^[2] Department of Cellular Biochemistry, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany. ^[3] Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), Göttingen, Germany. ^[4] Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany. katherine.bohnsack@med.uni-goettingen.de. ^[5] Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany. markus.bohnsack@med.uni-goettingen.de. ^[6] Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), Göttingen, Germany. markus.bohnsack@med.uni-goettingen.de. ^[7] Göttingen Center for Molecular Biosciences, Georg-August University Göttingen, Justus-von-Liebig-Weg 11, Göttingen, 37077, Germany. markus.bohnsack@med.uni-goettingen.de. ^[8]