First-in-human in vivo imaging and quantification of monoacylglycerol lipase in the brain: a PET study with <sup>18</sup>F-T-401.

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第一作者： Keisuke,Takahata

第一单位： Department of Functional Brain Imaging, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. takahata.keisuke@qst.go.jp.;Department of Neuro-Psychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan. takahata.keisuke@qst.go.jp.

作者： Keisuke,Takahata ^[1] ; Chie,Seki ^[2] ; Yasuyuki,Kimura ^[3] ; Manabu,Kubota ^[4] ; Masanori,Ichise ^[3] ; Yasunori,Sano ^[2] ; Yasuharu,Yamamoto ^[2] ; Kenji,Tagai ^[2] ; Hitoshi,Shimada ^[5] ; Soichiro,Kitamura ^[2] ; Kiwamu,Matsuoka ^[2] ; Hironobu,Endo ^[2] ; Hitoshi,Shinotoh ^[2] ; Kazunori,Kawamura ^[6] ; Ming-Rong,Zhang ^[6] ; Yuhei,Takado ^[2] ; Makoto,Higuchi ^[2]

作者单位： Department of Functional Brain Imaging, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. takahata.keisuke@qst.go.jp.;Department of Neuro-Psychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan. takahata.keisuke@qst.go.jp. ^[1] Department of Functional Brain Imaging, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. ^[2] Department of Functional Brain Imaging, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan.;Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi, Japan. ^[3] Department of Functional Brain Imaging, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan.;Department of Psychiatry, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawara-cho, Sakyo-ku, Kyoto, Japan. ^[4] Department of Functional Brain Imaging, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan.;Department of Functional Neurology & Neurosurgery, Center for Integrated Human Brain Science, Brain Research Institute, Niigata University, 1-757 Asahimachi-Dori, Chuo, Niigata, Niigata, Japan. ^[5] Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage, Chiba, Chiba, Japan. ^[6]

关键词 18F-T-401 Endocannabinoid MAGL Monoacylglycerol lipase PET