Can the tumor-agnostic evaluation of MSI/MMR status be the common denominator for the immunotherapy treatment of patients with several solid tumors?

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第一作者： Daniele,Fanale

第一单位： Section of Medical Oncology, Department of Surgical, Oncological and Oral Sciences, University of Palermo, 90127, Palermo, Italy.

作者： Daniele,Fanale ^[1] ; Lidia Rita,Corsini ^[1] ; Raimondo,Scalia ^[1] ; Chiara,Brando ^[1] ; Alessandra,Cucinella ^[1] ; Giorgio,Madonia ^[1] ; Alessandra,Dimino ^[1] ; Clarissa,Filorizzo ^[1] ; Nadia,Barraco ^[1] ; Marco,Bono ^[1] ; Alessia,Fiorino ^[1] ; Luigi,Magrin ^[1] ; Roberta,Sciacchitano ^[1] ; Alessandro,Perez ^[1] ; Tancredi Didier Bazan,Russo ^[1] ; Gianni,Pantuso ^[2] ; Antonio,Russo ^[3] ; Viviana,Bazan ^[4]

作者单位： Section of Medical Oncology, Department of Surgical, Oncological and Oral Sciences, University of Palermo, 90127, Palermo, Italy. ^[1] Unit of Oncological Surgery, Department of Surgical, Oncological and Oral Sciences, University of Palermo, 90127, Palermo, Italy. ^[2] Section of Medical Oncology, Department of Surgical, Oncological and Oral Sciences, University of Palermo, 90127, Palermo, Italy. Electronic address: antonio.russo@usa.net. ^[3] Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, 90127, Palermo, Italy. ^[4]

关键词 Colorectal cancer Immunotherapy MMR MMR deficiency MSI PD-1/PD-L1 Solid tumors Tumor-agnostic therapy

主题词结直肠肿瘤(Colorectal Neoplasms);DNA错配修复(DNA Mismatch Repair);人类(Humans);免疫疗法(Immunotherapy);微卫星不稳定性(Microsatellite Instability);肿瘤(Neoplasms)

DOI 10.1016/j.critrevonc.2022.103597

PMID 35033663

发布时间 2022-02-08

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