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Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors.

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第一作者： Mania,Ackermann

第一单位： Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.;REBIRTH, Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.;Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.

作者： Mania,Ackermann ^[1] ; Anna,Rafiei Hashtchin ^[2] ; Felix,Manstein ^[3] ; Marco,Carvalho Oliveira ^[2] ; Henning,Kempf ^[4] ; Robert,Zweigerdt ^[3] ; Nico,Lachmann ^[5]

作者单位： Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.;REBIRTH, Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.;Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. ^[1] Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.;REBIRTH, Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany. ^[2] REBIRTH, Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.;Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany. ^[3] Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.;Department of Stem Cell Biology, Novo Nordisk A/S, Måløv, Denmark. ^[4] Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany. Lachmann.Nico@mh-hannover.de.;REBIRTH, Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany. Lachmann.Nico@mh-hannover.de.;Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. Lachmann.Nico@mh-hannover.de.;Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany. Lachmann.Nico@mh-hannover.de.;Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. Lachmann.Nico@mh-hannover.de. ^[5]

医学主题词诱导多能干细胞(Induced Pluripotent Stem Cells);人类(Humans);生物反应器(Bioreactors);细胞培养技术(Cell Culture Techniques);巨噬细胞(Macrophages);细胞分化(Cell Differentiation)

DOI 10.1038/s41596-021-00654-7

PMID 35039668

发布时间 2025-05-30

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