Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay.

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作者： Caterina,Virginio ^[1] ; Laura,Aldegheri ^[2] ; Selena,Nola ^[2] ; Daniela,Brodbeck ^[2] ; Laurent,Brault ^[2] ; Luca F,Raveglia ^[2] ; Alessio,Barilli ^[2] ; Mark,Sabat ^[3] ; Richard,Myers ^[3]

作者单位： Aptuit, an Evotec Company, Via Alessandro Fleming, 4, 37135 Verona, Italy. Electronic address: caterina.virginio@evotec.com. ^[1] Aptuit, an Evotec Company, Via Alessandro Fleming, 4, 37135 Verona, Italy. ^[2] Takeda Pharmaceuticals, 9625 Towne Centre Drive, San Diego, CA 92121, United States. ^[3]

关键词 Automated patch clamp Cell-based assay Fluorescence methods Ion channels TRPM5

主题词电生理学现象(Electrophysiological Phenomena);荧光染料(Fluorescent Dyes);高通量筛选分析(High-Throughput Screening Assays);膜电位(Membrane Potentials);TRPM阳离子通道(TRPM Cation Channels);瞬时受体电位通道(Transient Receptor Potential Channels)

DOI 10.1016/j.slasd.2021.10.004

PMID 35058176

发布时间 2022-05-03

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SLAS discovery

2022年27卷1期

55-64页

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Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay.

SLAS discovery

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Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay.

SLAS discovery

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SLAS discovery

相关期刊

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