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SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors.

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第一作者： Dan,Li

第一单位： School of Medicine and Institute for Immunology, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, Beijing 100084, China.

作者： Dan,Li ^[1] ; Wei,Xiong ^[1] ; Yuande,Wang ^[1] ; Jin,Feng ^[1] ; Yuexi,He ^[1] ; Juan,Du ^[2] ; Jing,Wang ^[3] ; Meixiang,Yang ^[4] ; Hui,Zeng ^[2] ; Yong-Guang,Yang ^[5] ; Ning,Wu ^[6] ; Shasha,Chen ^[7] ; Zhongjun,Dong ^[8]

作者单位： School of Medicine and Institute for Immunology, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, Beijing 100084, China. ^[1] Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China. ^[2] Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. ^[3] Biomedical Translational Research Institute, Jinan University, Guangzhou 510632, China. ^[4] First Bethune Hospital and International Center of Future Science, Jilin University, Changchun 130061, China. ^[5] Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. ^[6] Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. ^[7] School of Medicine and Institute for Immunology, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, Beijing 100084, China.;School of Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 271016, China. ^[8]

医学主题词动物(Animals);细胞系(Cell Line);血液肿瘤(Hematologic Neoplasms);人类(Humans);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小鼠, 转基因(Mice, Transgenic);吞噬作用(Phagocytosis)

DOI 10.1126/sciimmunol.abj5501

PMID 35061505

发布时间 2022-03-08

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