Control of backbone chemistry and chirality boost oligonucleotide splice switching activity.

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作者： Pachamuthu,Kandasamy ^[1] ; Graham,McClorey ^[2] ; Mamoru,Shimizu ^[1] ; Nayantara,Kothari ^[1] ; Rowshon,Alam ^[1] ; Naoki,Iwamoto ^[1] ; Jayakanthan,Kumarasamy ^[1] ; Gopal R,Bommineni ^[1] ; Adam,Bezigian ^[1] ; Onanong,Chivatakarn ^[1] ; David C D,Butler ^[1] ; Michael,Byrne ^[1] ; Katarzyna,Chwalenia ^[2] ; Kay E,Davies ^[3] ; Jigar,Desai ^[1] ; Juili Dilip,Shelke ^[1] ; Ann F,Durbin ^[1] ; Ruth,Ellerington ^[2] ; Ben,Edwards ^[3] ; Jack,Godfrey ^[1] ; Andrew,Hoss ^[1] ; Fangjun,Liu ^[1] ; Kenneth,Longo ^[1] ; Genliang,Lu ^[4] ; Subramanian,Marappan ^[1] ; Jacopo,Oieni ^[1] ; Ik-Hyeon,Paik ^[2] ; Erin Purcell,Estabrook ^[1] ; Chikdu,Shivalila ^[1] ; Maeve,Tischbein ^[1] ; Tomomi,Kawamoto ^[1] ; Carlo,Rinaldi ^[1] ; Joana,Rajão-Saraiva ^[2] ; Snehlata,Tripathi ^[4] ; Hailin,Yang ^[3] ; Yuan,Yin ^[1] ; Xiansi,Zhao ^[1] ; Cong,Zhou ^[1] ; Jason,Zhang ^[1] ; Luciano,Apponi ^[1] ; Matthew J A,Wood ^[1] ; Chandra,Vargeese ^[1]

作者单位： Wave Life Sciences, Cambridge, MA, USA. ^[1] Department of Paediatrics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. ^[2] Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3PT, UK. ^[3] MDUK Oxford Neuromuscular Centre, University of Oxford, Oxford OX2 9DU, UK. ^[4]