Topiroxostat versus allopurinol in patients with chronic heart failure complicated by hyperuricemia: A prospective, randomized, open-label, blinded-end-point clinical trial.

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作者： Masashi,Sakuma ^[1] ; Shigeru,Toyoda ^[1] ; Takuo,Arikawa ^[1] ; Yota,Koyabu ^[1] ; Toru,Kato ^[2] ; Taichi,Adachi ^[3] ; Hideaki,Suwa ^[3] ; Jun-Ichi,Narita ^[4] ; Koetsu,Anraku ^[5] ; Kimihiko,Ishimura ^[5] ; Fumitake,Yamauchi ^[6] ; Yasunori,Sato ^[7] ; Teruo,Inoue ^[1]

作者单位： Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Japan. ^[1] Department of Clinical Research, National Hospital Organization Tochigi Medical Center, Utsunomiya, Japan. ^[2] Department of Cardiology, National Hospital Organization Tochigi Medical Center, Utsunomiya, Japan. ^[3] Department of Neurosurgery, Tochigi Medical Center Tochinoki, Tochigi, Japan. ^[4] Department of Internal Medicine, Tochigi Medical Center Tochinoki, Tochigi, Japan. ^[5] Department of Cardiology, Yuai Memorial Hospital, Koga, Japan. ^[6] Department of Preventive Medicine and Public Health, Keio University School of Medicine, Shinanomachi, Japan. ^[7]

主题词老年人(Aged);老年人, 80以上(Aged, 80 and over);别嘌呤醇(Allopurinol);女(雌)性(Female);心力衰竭(Heart Failure);人类(Humans);高尿酸血症(Hyperuricemia);男(雄)性(Male);中年人(Middle Aged);利钠肽, 脑(Natriuretic Peptide, Brain);腈类(Nitriles);肽碎片(Peptide Fragments);前瞻性研究(Prospective Studies);吡啶类(Pyridines);每搏输出量(Stroke Volume);治疗结果(Treatment Outcome)

DOI 10.1371/journal.pone.0261445

PMID 35077456

发布时间 2022-02-10

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Topiroxostat versus allopurinol in patients with chronic heart failure complicated by hyperuricemia: A prospective, randomized, open-label, blinded-end-point clinical trial.

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Topiroxostat versus allopurinol in patients with chronic heart failure complicated by hyperuricemia: A prospective, randomized, open-label, blinded-end-point clinical trial.

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