AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens.

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作者： Chenkai,Li ^[1] ; Darcy,Sutherland ^[2] ; S Austin,Hammond ^[3] ; Chen,Yang ^[1] ; Figali,Taho ^[1] ; Lauren,Bergman ^[4] ; Simon,Houston ^[4] ; René L,Warren ^[3] ; Titus,Wong ^[5] ; Linda M N,Hoang ^[6] ; Caroline E,Cameron ^[7] ; Caren C,Helbing ^[4] ; Inanc,Birol ^[8]

作者单位： Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, V5Z 4S6, Canada.;Bioinformatics Graduate Program, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. ^[1] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, V5Z 4S6, Canada.;Public Health Laboratory, British Columbia Centre for Disease Control, Vancouver, BC, V5Z 4R4, Canada.;Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. ^[2] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, V5Z 4S6, Canada. ^[3] Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8P 5C3, Canada. ^[4] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.;Medical Microbiology Laboratory, Vancouver General Hospital, Vancouver, BC, V5Z 1M9, Canada. ^[5] Public Health Laboratory, British Columbia Centre for Disease Control, Vancouver, BC, V5Z 4R4, Canada.;Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. ^[6] Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8P 5C3, Canada.;Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, 98195, USA. ^[7] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, V5Z 4S6, Canada. ibirol@bcgsc.ca.;Public Health Laboratory, British Columbia Centre for Disease Control, Vancouver, BC, V5Z 4R4, Canada. ibirol@bcgsc.ca.;Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. ibirol@bcgsc.ca.;Department of Medical Genetics, University of British Columbia, Vancouver, BC, V6H 3N1, Canada. ibirol@bcgsc.ca. ^[8]

关键词 Antimicrobial peptide Attention mechanism Deep learning

主题词抗菌药(Anti-Bacterial Agents);抗微生物阳离子肽类(Antimicrobial Cationic Peptides);注意力(Attention);世界卫生组织(World Health Organization)

DOI 10.1186/s12864-022-08310-4

PMID 35078402

发布时间 2024-12-07

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准确一般字义偏差语意偏离译文作用小提交