首页> Cell reports> Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.

Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.

导出 OA

翻译打印收藏纠错

第一作者： Yumei,Li

第一单位： Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

作者： Yumei,Li ^[1] ; Yanwen,Zhu ^[1] ; Shu,Feng ^[1] ; Yuji,Ishida ^[2] ; Tsu-Pei,Chiu ^[3] ; Takeshi,Saito ^[4] ; Sean,Wang ^[5] ; David K,Ann ^[6] ; Jing-Hsiung James,Ou ^[7]

作者单位： Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. ^[1] Department of Medicine, Division of Gastrointestinal and Liver Diseases, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; PhoenixBio, Kagamiyama, Higashi-Hiroshima, Hiroshima, Japan. ^[2] Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA. ^[3] Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Department of Medicine, Division of Gastrointestinal and Liver Diseases, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. ^[4] Michael Amini Transfusion Medicine Center, City of Hope, Duarte, CA, USA. ^[5] Beckman Research Institute, City of Hope, Duarte, CA, USA. ^[6] Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. Electronic address: jamesou@usc.edu. ^[7]

关键词 IL-1β signaling M1-like and M2-like macrophages hepatitis B virus metabolic reprogramming oxidative phosphorylation transcriptional regulation