Atezolizumab and bevacizumab with transarterial chemoembolization in hepatocellular carcinoma: the DEMAND trial protocol.

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第一作者： Najib,Ben Khaled

第一单位： Department of Medicine II, University Hospital, LMU Munich, Munich, 81377, Germany.

作者： Najib,Ben Khaled ^[1] ; Max,Seidensticker ^[2] ; Jens,Ricke ^[2] ; Julia,Mayerle ^[1] ; Bettina,Oehrle ^[1] ; Daniel,Rössler ^[1] ; Daniel,Teupser ^[3] ; Ursula,Ehmer ^[4] ; Michael,Bitzer ^[5] ; Dirk,Waldschmidt ^[6] ; Martin,Fuchs ^[7] ; Philipp A,Reuken ^[8] ; Christian M,Lange ^[1] ; Henning,Wege ^[9] ; Arne,Kandulski ^[10] ; Alexander,Dechêne ^[11] ; Marino,Venerito ^[12] ; Marie-Luise,Berres ^[13] ; Tom,Luedde ^[14] ; Ilja,Kubisch ^[15] ; Florian P,Reiter ^[16] ; Enrico N,De Toni ^[17]

作者单位： Department of Medicine II, University Hospital, LMU Munich, Munich, 81377, Germany. ^[1] Department of Radiology, University Hospital, LMU Munich, Munich, 81377, Germany. ^[2] Institute of Laboratory Medicine, University Hospital, LMU Munich, Munich, 81377, Germany. ^[3] Internal Medicine II, Klinikum rechts der Isar, TU München, Munich, 81675, Germany. ^[4] Department for Internal Medicine I & Center for Personalized Medicine, Eberhard-Karls University, Tübingen, 72016, Germany. ^[5] Department of Gastroenterology, University Hospital of Cologne, Cologne, 50937, Germany. ^[6] Department of Gastroenterology, Hepatology & GI-Oncology, Munich Hospital Bogenhausen, Munich, 81925, Germany. ^[7] Department of Internal Medicine IV, Jena University Hospital, Jena, 07743, Germany. ^[8] Department of Gastroenterology & Hepatology, University Hospital Essen, Essen, 45147, Germany. ^[9] Cancer Center Esslingen, Medical Center Esslingen, Esslingen, 73730, Germany. ^[10] Department of Gastroenterology, University Hospital Regensburg, Regensburg, 93053, Germany. ^[11] Department of Gastroenterology, Hepatology & Endocrinology, General Hospital Nuremberg, Nuremberg, 90419, Germany. ^[12] Department of Gastroenterology, Hepatology & Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, 39120, Germany. ^[13] Medical Department III, University Hospital of Aachen, Aachen, 52074, Germany. ^[14] Clinic for Gastroenterology, Hepatology & Infectious Diseases, University Hospital of Düsseldorf, Düsseldorf, 40225, Germany. ^[15] Department of Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, Metabolic Disorders, Oncology, Klinikum Chemnitz gGmbH, Chemnitz, 09116, Germany. ^[16] Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, 97080, Germany. ^[17]

关键词 BCLC B PD-L1 VEGF atezolizumab bevacizumab hepatocellular carcinoma immunotherapy liver cancer transarterial chemoembolization