Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.-论文-万方医学网

第一作者： Guadalupe J,Jasso

第一单位： Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.;Harvard Medical School, Boston, Massachusetts, United States of America.

作者： Guadalupe J,Jasso ^[1] ; Alok,Jaiswal ^[2] ; Mukund,Varma ^[2] ; Tyler,Laszewski ^[3] ; Angelo,Grauel ^[3] ; Abdifatah,Omar ^[4] ; Nilsa,Silva ^[3] ; Glenn,Dranoff ^[3] ; Jeffrey A,Porter ^[3] ; Keith,Mansfield ^[3] ; Viviana,Cremasco ^[3] ; Aviv,Regev ^[5] ; Ramnik J,Xavier ^[6] ; Daniel B,Graham ^[7]

作者单位： Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.;Harvard Medical School, Boston, Massachusetts, United States of America. ^[1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America. ^[2] Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America. ^[3] Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America. ^[4] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.;Howard Hughes Medical Institute and David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America. ^[5] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.;Harvard Medical School, Boston, Massachusetts, United States of America.;Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.;Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.;Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.;Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America. ^[6] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.;Harvard Medical School, Boston, Massachusetts, United States of America.;Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.;Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.;Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America. ^[7]

医学主题词 ADAM蛋白质类(ADAM Proteins);动物(Animals);细胞分化(Cell Differentiation);结肠炎(Colitis);结肠(Colon);细胞外基质(Extracellular Matrix);成纤维细胞(Fibroblasts);纤维化(Fibrosis);基因表达调控(Gene Expression Regulation);人类(Humans);炎症(Inflammation);白细胞介素11(Interleukin-11);肠黏膜(Intestinal Mucosa);男(雄)性(Male);间质干细胞(Mesenchymal Stem Cells);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);序列分析, RNA(Sequence Analysis, RNA);单细胞分析(Single-Cell Analysis);十二烷硫酸钠(Sodium Dodecyl Sulfate);转录, 遗传(Transcription, Genetic);伤口愈合(Wound Healing)

DOI 10.1371/journal.pbio.3001532

PMID 35085231

发布时间 2022-03-02

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Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.

PLoS biology

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Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.

PLoS biology

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PLoS biology

相关期刊

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