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首页> Toxicology and applied pharmacology> Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro.

Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro.

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作者： Yan,Tang ^[1] ; Han,Yang ^[2] ; Jinsong,Yu ^[3] ; Zhong,Li ^[1] ; Quanxiao,Xu ^[4] ; Bo,Ding ^[1] ; Guangwei,Jia ^[5]

作者单位： Department of General Surgery, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, Henan 473004, China. ^[1] Department of Endocrinology, Nanshi Hospital Affiliated to Henan University, Nanyang, Henan 473065, China. ^[2] Department of Thyroid and Breast Surgery, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, Henan 473004, China; Key Laboratory of Thyroid Tumor Prevention and Treatment of Nanyang, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, Henan 473004, China. ^[3] Department of Oncology, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, Henan 473004, China. ^[4] Department of Thyroid and Breast Surgery, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, Henan 473004, China; Key Laboratory of Thyroid Tumor Prevention and Treatment of Nanyang, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, Henan 473004, China. Electronic address: jiaguangwei2022@163.com. ^[5]

关键词 Apoptosis Crocin PTPN4 Reactive oxygen species miR-34a-5p

主题词细胞凋亡(Apoptosis);类胡萝卜素类(Carotenoids);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);L-乳酸脱氢酶(L-Lactate Dehydrogenase);微RNAs(MicroRNAs);蛋白质酪氨酸磷酸酶, 非受体4型(Protein Tyrosine Phosphatase, Non-Receptor Type 4);活性氧(Reactive Oxygen Species);甲状腺肿瘤(Thyroid Neoplasms)

DOI 10.1016/j.taap.2022.115892

PMID 35085590

发布时间 2022-03-03

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Toxicology and applied pharmacology

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