A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping.

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作者： Savannah J,Lusk ^[1] ; Andrew,McKinney ^[1] ; Patrick J,Hunt ^[2] ; Paul G,Fahey ^[1] ; Jay,Patel ^[1] ; Andersen,Chang ^[3] ; Jenny J,Sun ^[1] ; Vena K,Martinez ^[4] ; Ping Jun,Zhu ^[1] ; Jeremy R,Egbert ^[5] ; Genevera,Allen ^[6] ; Xiaolong,Jiang ^[7] ; Benjamin R,Arenkiel ^[1] ; Andreas S,Tolias ^[2] ; Mauro,Costa-Mattioli ^[8] ; Russell S,Ray ^[1]

作者单位： Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. ^[1] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. ^[2] Department of Statistics, Rice University, Houston, TX, USA. ^[3] Department of Pharmacology, Baylor College of Medicine, Houston, TX, USA. ^[4] Department of Cell Biology, University of Connecticut, Farmington, CT, USA. ^[5] Department of Statistics, Computer Science, and Electrical and Computer Engineering, Rice University, Houston, TX, USA. ^[6] Neurological Research Institute, Baylor College of Medicine, Houston, TX, USA. ^[7] McNair Medical Institute, Houston, TX, USA. ^[8] Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. russell.ray@bcm.edu. ^[9] McNair Medical Institute, Houston, TX, USA. russell.ray@bcm.edu. ^[10]

关键词 CRISPR/Cas9 Cre DREADDs Dre Flp Fluorescent reporter Gene targeting Intersectional genetics