A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish.

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作者： Sumeet Pal,Singh ^[1] ; Prateek,Chawla ^[2] ; Alisa,Hnatiuk ^[2] ; Margrit,Kamel ^[2] ; Luis Delgadillo,Silva ^[2] ; Bastiaan,Spanjaard ^[3] ; Sema Elif,Eski ^[1] ; Sharan,Janjuha ^[4] ; Pedro,Olivares-Chauvet ^[3] ; Oezge,Kayisoglu ^[5] ; Fabian,Rost ^[2] ; Juliane,Bläsche ^[6] ; Annekathrin,Kränkel ^[6] ; Andreas,Petzold ^[6] ; Thomas,Kurth ^[6] ; Susanne,Reinhardt ^[7] ; Jan Philipp,Junker ^[6] ; Nikolay,Ninov ^[3]

作者单位： IRIBHM, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium. ^[1] Center for Regenerative Therapies Dresden, Technische Universität Dresden, 01307 Dresden, Germany. ^[2] Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, 10115 Berlin, Germany. ^[3] Institute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zurich, Switzerland. ^[4] The Julius Maximilian University of Wurzburg, 97070 Wurzburg, Germany. ^[5] DRESDEN-concept Genome Center, DFG NGS Competence Center, c/o Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, 01307 Dresden, Germany. ^[6] TUD, Center for Molecular and Cellular Bioengineering (CMCB), Technology Platform, EM-Facility, Technische Universitaät Dresden, 01307 Dresden, Germany. ^[7] Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Hospital and Faculty of Medicine Carl Gustav Carus of Technische Universität Dresden, 01307 Dresden, Germany. ^[8]

关键词 Beta-cell Cell fate Cell plasticity Diabetes Gamma-cell Insulin Pancreas Regeneration Single cell Zebrafish