首页> Journal of clinical epidemiology> Identification of threshold for large (dramatic) effects that would obviate randomized trials is not possible.

Identification of threshold for large (dramatic) effects that would obviate randomized trials is not possible.

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第一作者： Iztok,Hozo

第一单位： Department of Mathematics, Indiana University Northwest, Gary, IN.

作者： Iztok,Hozo ^[1] ; Benjamin,Djulbegovic ^[2] ; Austin J,Parish ^[3] ; John P A,Ioannidis ^[4]

作者单位： Department of Mathematics, Indiana University Northwest, Gary, IN. ^[1] Beckman Research Institute, City of Hope Institution, Duarte, CA; Department of Computational and Quantitative Medicine, City of Hope Institution, Duarte, CA; Division of Health Analytics; Evidence-based Medicine and Comparative Effectiveness Research, 1500 East Duarte Road, Duarte, CA. Electronic address: bdjulbegovic@coh.org. ^[2] Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA; Department of Emergency Medicine, Lincoln Medical Center, Bronx, New York. ^[3] Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA; Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California, Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA. ^[4]

关键词 FDA large or dramatic treatment effects methodology observational studies randomized trials statistical modeling

医学主题词人类(Humans);比值比(Odds Ratio);随机对照试验(主题)(Randomized Controlled Trials as Topic)

DOI 10.1016/j.jclinepi.2022.01.016

PMID 35091046

发布时间 2023-05-02

基金项目

R01 CA133594/CA/NCI NIH HHS/United States R01 CA140408/CA/NCI NIH HHS/United States R01 NS052956/NS/NINDS NIH HHS/United States

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