Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity.

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作者： Iredia D,Iyamu ^[1] ; Yingzhao,Zhao ^[1] ; Prakash T,Parvatkar ^[1] ; Bracken F,Roberts ^[2] ; Debora R,Casandra ^[3] ; Lukasz,Wojtas ^[4] ; Dennis E,Kyle ^[5] ; Debopam,Chakrabarti ^[2] ; Roman,Manetsch ^[6]

作者单位： Department of Chemistry and Chemical Biology, College of Science, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA. ^[1] Molecular Microbiology Division, Burnett School of Biomedical Science, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826, USA. ^[2] Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL 33612, USA. ^[3] Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. ^[4] Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL 33612, USA; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, 500 D.W. Brooks Dr, Athens, GA 30602, USA. ^[5] Department of Chemistry and Chemical Biology, College of Science, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA; Department of Pharmaceutical Sciences, Bouvé College of Pharmacy, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA; Center for Drug Discovery, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA. ^[6]

关键词 Antimalarial Drug resistance Natural products Spirocyclic chromane Structure-activity relationship Structure-property relationship