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Sex differences in cognitive resilience in preclinical autosomal-dominant Alzheimer's disease carriers and non-carriers: Baseline findings from the API ADAD Colombia Trial.

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第一作者： Clara,Vila-Castelar

第一单位： Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

作者： Clara,Vila-Castelar ^[1] ; Pierre N,Tariot ^[2] ; Kaycee M,Sink ^[3] ; David,Clayton ^[3] ; Jessica B,Langbaum ^[2] ; Ronald G,Thomas ^[4] ; Yinghua,Chen ^[2] ; Yi,Su ^[2] ; Kewei,Chen ^[2] ; Nan,Hu ^[3] ; Margarita,Giraldo-Chica ^[5] ; Carlos,Tobón ^[5] ; Natalia,Acosta-Baena ^[5] ; Ernesto,Luna ^[5] ; Marisol,Londoño ^[5] ; Paula,Ospina ^[5] ; Victoria,Tirado ^[5] ; Claudia,Muñoz ^[5] ; Eliana,Henao ^[5] ; Yamile,Bocanegra ^[5] ; Sergio,Alvarez ^[6] ; Silvia,Rios-Romenets ^[5] ; Valentina,Ghisays ^[2] ; Dhruman,Goradia ^[2] ; Wendy,Lee ^[2] ; Ji,Luo ^[2] ; Michael H,Malek-Ahmadi ^[2] ; Hillary D,Protas ^[2] ; Francisco,Lopera ^[5] ; Eric M,Reiman ^[2] ; Yakeel T,Quiroz ^[7] ; API ADAD Colombia Trial Group

作者单位： Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. ^[1] Banner Alzheimer's Institute, Phoenix, Arizona, USA. ^[2] Genentech Inc., South San Francisco, California, USA. ^[3] University of California, San Diego, California, USA. ^[4] Grupo de Neurociencias de Antioquia of Universidad de Antioquia, Medellin, CO, Colombia. ^[5] Hospital Pablo Tobon Uribe, Medellin, CO, Colombia. ^[6] Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.;Banner Alzheimer's Institute, Phoenix, Arizona, USA. ^[7]

关键词 Alzheimer's disease autosomal-dominant Alzheimer's disease cognition neurodegeneration pathology preclinical sex differences

医学主题词成年人(Adult);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);阿尔茨海默病(Alzheimer Disease);认知(Cognition);哥伦比亚(Colombia);神经心理学测验(Neuropsychological Tests);早老素1(Presenilin-1);性征(Sex Characteristics)

DOI 10.1002/alz.12552

PMID 35103388

发布时间 2024-09-06

基金项目

R01 AG058468/AG/NIA NIH HHS/United States R01 AG055444/AG/NIA NIH HHS/United States R01 AG031581/AG/NIA NIH HHS/United States R01 AG063954/AG/NIA NIH HHS/United States R01 AG054671/AG/NIA NIH HHS/United States P30 AG072980/AG/NIA NIH HHS/United States P30 AG019610/AG/NIA NIH HHS/United States DP5 OD019833/OD/NIH HHS/United States RF1 AG041705/AG/NIA NIH HHS/United States

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