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首页> Bioorganic chemistry> Dimethoxyindoles based thiosemicarbazones as multi-target agents; synthesis, crystal interactions, biological activity and molecular modeling.

Dimethoxyindoles based thiosemicarbazones as multi-target agents; synthesis, crystal interactions, biological activity and molecular modeling.

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第一作者： Minhal,Yıldız

第一单位： Department of Chemistry, Faculty of Art and Science, Tekirdag Namık Kemal University, Turkey.

作者： Minhal,Yıldız ^[1] ; Murat,Bingul ^[2] ; Yunus,Zorlu ^[3] ; Mehmet F,Saglam ^[3] ; Mehmet,Boga ^[4] ; Mutesir,Temel ^[3] ; Mehmet Serdar,Koca ^[5] ; Hakan,Kandemir ^[1] ; Ibrahim F,Sengul ^[6]

作者单位： Department of Chemistry, Faculty of Art and Science, Tekirdag Namık Kemal University, Turkey. ^[1] Department of Basic Pharmaceutical Chemistry, Faculty of Pharmacy, Dicle University, Diyarbakır 21280, Turkey. ^[2] Department of Chemistry, Faculty of Science, Gebze Technical University, Kocaeli, Turkey. ^[3] Department of Analytical Chemistry, Faculty of Pharmacy, Dicle University, Diyarbakır 21280, Turkey. ^[4] Department of Molecular Biology and Genetics, Faculty of Science, Gebze Technical University, Kocaeli, Turkey. ^[5] Department of Chemistry, Faculty of Science, Gebze Technical University, Kocaeli, Turkey. Electronic address: fazilsengul@gtu.edu.tr. ^[6]

关键词 Antioxidant Cholinesterase inhibitor Dimethoxyindoles Molecular modelling Thiosemicarbazones

主题词乙酰胆碱酯酶(Acetylcholinesterase);老年人(Aged);阿尔茨海默病(Alzheimer Disease);抗氧化剂(Antioxidants);丁酰胆碱酯酶(Butyrylcholinesterase);胆碱酯酶抑制剂(Cholinesterase Inhibitors);人类(Humans);中年人(Middle Aged);分子动力学模拟(Molecular Dynamics Simulation);神经变性疾病(Neurodegenerative Diseases);缩氨硫脲类(Thiosemicarbazones)

DOI 10.1016/j.bioorg.2022.105647

PMID 35121556

发布时间 2022-06-30

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