Latent TGFβ complexes are transglutaminase cross-linked to fibrillin to facilitate TGFβ activation.

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作者： Michael P,Lockhart-Cairns ^[1] ; Stuart A,Cain ^[1] ; Rana,Dajani ^[1] ; Ruth,Steer ^[1] ; Jennifer,Thomson ^[1] ; Yasmene F,Alanazi ^[2] ; Cay M,Kielty ^[1] ; Clair,Baldock ^[3]

作者单位： Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK. ^[1] Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK; Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia. ^[2] Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK. Electronic address: clair.baldock@manchester.ac.uk. ^[3]

关键词 LTBP TGFbeta activation fibrillin transglutaminase-2

主题词细胞外基质(Extracellular Matrix);潜在性TGFβ结合蛋白质类(Latent TGF-beta Binding Proteins);微丝蛋白质类(Microfilament Proteins);转化生长因子β(Transforming Growth Factor beta);转谷酰胺酶(Transglutaminases)

DOI 10.1016/j.matbio.2022.01.005

PMID 35122964

发布时间 2022-03-26

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