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首页> Molecular medicine (Cambridge, Mass.)> Increased plasmablasts enhance T cell-mediated beta cell destruction and promote the development of type 1 diabetes.

Increased plasmablasts enhance T cell-mediated beta cell destruction and promote the development of type 1 diabetes.

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作者： Qing,Ling ^[1] ; Lei,Shen ^[2] ; Wei,Zhang ^[1] ; DuoDuo,Qu ^[1] ; Hongdong,Wang ^[1] ; Bin,Wang ^[3] ; Yong,Liu ^[4] ; Jing,Lu ^[5] ; Dalong,Zhu ^[6] ; Yan,Bi ^[7]

作者单位： Department of Endocrinology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. ^[1] Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[2] Clinical Stem Cell Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. ^[3] Department of Laboratory Medicine, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. ^[4] Department of Endocrinology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. lujingsnow@126.com. ^[5] Department of Endocrinology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. zhudalong@nju.edu.cn. ^[6] Department of Endocrinology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. biyan@nju.edu.cn. ^[7]

关键词 Autoimmunity B cell subset Plasmablast T cell Type 1 diabetes

主题词动物(Animals);病例对照研究(Case-Control Studies);糖尿病, 1型(Diabetes Mellitus, Type 1);疾病模型, 动物(Disease Models, Animal);疾病易感性(Disease Susceptibility);女(雌)性(Female);人类(Humans);免疫组织化学(Immunohistochemistry);免疫表型分型(Immunophenotyping);胰岛素分泌细胞(Insulin-Secreting Cells);淋巴细胞活化(Lymphocyte Activation);男(雄)性(Male);小鼠, SCID(Mice, SCID);T淋巴细胞(T-Lymphocytes);小鼠(Mice)

DOI 10.1186/s10020-022-00447-y

PMID 35123388

发布时间 2024-02-26

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Molecular medicine (Cambridge, Mass.)

Molecular medicine (Cambridge, Mass.)

2022年28卷1期

18页

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