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Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy.

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第一作者: Xianbin,Ma
第一单位: Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy & Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing 400715, China.
作者: Xianbin,Ma [1] ; Shaochen,Yang [2] ; Tian,Zhang [1] ; Shuo,Wang [2] ; Qichao,Yang [2] ; Yao,Xiao [2] ; Xiaoxiao,Shi [3] ; Peng,Xue [1] ; Yuejun,Kang [1] ; Gang,Liu [3] ; Zhi-Jun,Sun [2] ; Zhigang,Xu [1]
作者单位: Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy & Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing 400715, China. [1] The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China. [2] State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China. [3]
关键词 5-ALA, 5-aminolevulinic acid5-FU, 5-fluorouracilALKP, alkaline phosphataseALT, alanine aminotransferaseAPCs, antigen-presenting cellsAST, aminotransferaseATP, adenosine triphosphateAUC, area under curvesBioresponsiveCLSM, confocal laser scanning microscopeCPT-11, irinotecanCRE, creatinineCRT, calreticulinCe6, chlorin e6ChemotherapyDAMPs, damage-associated molecular patternsDCs, dendritic cellsDDSs, drug delivery systemsDLN, draining lymph nodesDM NGs, doxorubicin-based mannose nanogelDOC, docetaxelDOX, doxorubicinDTT, d,l-dithiothreitolDoxorubicinFCM, flow cytometryFDA, Fluorescein diacetateGEM, gemcitabineGSH, glutathioneH&E, hematoxylin-eosinHCPT, 10-hydroxy camptothecinHCT, hematocritHGB, hemoglobin concentrationHMGB1, high migrating group box 1ICB, immune checkpoint blockadeICD, immunogenic cell deathICG, indocyanine GreenIHC, immunohistochemistryITM, immunosuppressive tumor microenvironmentImmunogenic cell deathImmunotherapyLDH, lactate dehydrogenaseLYM, lymphocyte ratioMAN, mannoseMCHC, mean corpuscular hemoglobin concentrationMCSs, multicellular spheroidsMFI, mean fluorescence intensityMPV, mean platelet volumeMannoseNGs, nanogelsNanogelOXA, oxaliplatinP18, purpurin 18PDI, polydispersity indexPLT, plateletsPTX, paclitaxelProdrugRBC, red blood cell countRDW, variation coefficient of red blood cell distribution widthTAAs, tumor-associated antigensTAM, tumor-associated macrophagesTGF-β, transforming growth factor-βTMA, tissue microarraysTME, tumor microenvironmentUrea, urea nitrogenWBC, white blood cell countirAEs, immune-related adverse events
DOI 10.1016/j.apsb.2021.05.016
PMID 35127398
发布时间 2022-02-08
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Acta pharmaceutica Sinica. B

Acta pharmaceutica Sinica. B

2022年12卷1期

451-466页

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