Common DNA methylation changes in biliary tract cancers identify subtypes with different immune characteristics and clinical outcomes.

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作者： Zhiquan,Qiu ^[1] ; Jun,Ji ^[2] ; Yu,Xu ^[3] ; Yan,Zhu ^[4] ; Chunfang,Gao ^[2] ; Guoqiang,Wang ^[3] ; Chengcheng,Li ^[3] ; Yuzi,Zhang ^[3] ; Jing,Zhao ^[3] ; Chenyang,Wang ^[5] ; Xiaofang,Wen ^[3] ; Zhou,Zhang ^[6] ; Bingsi,Li ^[5] ; Zhihong,Zhang ^[5] ; Shangli,Cai ^[3] ; Bin,Li ^[7] ; Xiaoqing,Jiang ^[8]

作者单位： Department of Biliary Tract Surgery I, Eastern Hepatobiliary Surgery Hospital, Secondary Military Medicine University, No. 225 Changhai Road, Shanghai, 200438, China. ^[1] Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Secondary Military Medicine University, Shanghai, China. ^[2] Department of Medicine, Burning Rock Biotech, Guangzhou, China. ^[3] Department of Pathology, Changhai Hospital, Shanghai, China. ^[4] Department of Research and Development, Burning Rock Biotech, Guangzhou, China. ^[5] Department of Bioinformatics, Burning Rock Biotech, Guangzhou, China. ^[6] Department of Biliary Tract Surgery I, Eastern Hepatobiliary Surgery Hospital, Secondary Military Medicine University, No. 225 Changhai Road, Shanghai, 200438, China. libinjeff@126.com. ^[7] Department of Biliary Tract Surgery I, Eastern Hepatobiliary Surgery Hospital, Secondary Military Medicine University, No. 225 Changhai Road, Shanghai, 200438, China. jxq1225@sina.com. ^[8]

关键词 Biliary tract cancer DNA methylation Immune characteristic Prognostication

主题词胆管肿瘤(Bile Duct Neoplasms);胆管, 肝内(Bile Ducts, Intrahepatic);胆道肿瘤(Biliary Tract Neoplasms);DNA拷贝数变异(DNA Copy Number Variations);DNA甲基化(DNA Methylation);人类(Humans);肿瘤微环境(Tumor Microenvironment)

DOI 10.1186/s12916-021-02197-w

PMID 35130881

发布时间 2022-03-23

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