Systemic calcitonin gene-related peptide receptor antagonism decreases survival in a porcine model of polymicrobial sepsis: blinded randomised controlled trial.

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第一作者： David A C,Messerer

第一单位： Institute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany; Department of Anesthesiology and Intensive Care Medicine, University Hospital Ulm, Ulm, Germany.

作者： David A C,Messerer ^[1] ; Thomas,Datzmann ^[2] ; Anke,Baranowsky ^[3] ; Leandra,Peschel ^[2] ; Andrea,Hoffmann ^[2] ; Michael,Gröger ^[2] ; Michael,Amling ^[4] ; Martin,Wepler ^[1] ; Benedikt L,Nussbaum ^[1] ; Shan,Jiang ^[3] ; Paul,Knapstein ^[3] ; Antonia,Donat ^[3] ; Enrico,Calzia ^[2] ; Peter,Radermacher ^[5] ; Johannes,Keller ^[6]

作者单位： Institute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany; Department of Anesthesiology and Intensive Care Medicine, University Hospital Ulm, Ulm, Germany. ^[1] Institute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany. ^[2] Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[3] Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[4] Institute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany. Electronic address: peter.radermacher@uni-ulm.de. ^[5] Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: j.keller@uke.de. ^[6]

关键词 CGRP receptor calcitonin gene-related peptide gepants migraine olcegepant peritonitis procalcitonin sepsis