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Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice.

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第一作者： Zhongnan,Xiao

第一单位： Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Beijing Rehabilitation Hospital, Capital Medical University, Beijing, 100144, China.

作者： Zhongnan,Xiao ^[1] ; Danmin,Shen ^[2] ; Ting,Lan ^[2] ; Chao,Wei ^[3] ; Weihua,Wu ^[2] ; Qingyu,Sun ^[3] ; Zhaoli,Luo ^[2] ; Wen,Chen ^[3] ; Yurui,Zhang ^[3] ; Liye,Hu ^[2] ; Chenguang,Zhang ^[2] ; Yamei,Wang ^[2] ; Yabin,Lu ^[2] ; Peipei,Wang ^[3] ; Fei,Yang ^[4] ; Qian,Li ^[5]

作者单位： Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Beijing Rehabilitation Hospital, Capital Medical University, Beijing, 100144, China. ^[1] Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. ^[2] Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. ^[3] Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, 100069, China. ^[4] Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, 100069, China. Electronic address: qianli@ccmu.edu.cn. ^[5]

关键词 Ferroptosis Hyperglycemia Intracerebral hemorrhagic stroke Lactoferrin Neutrophil PPARγ

医学主题词动物(Animals);脑出血(Cerebral Hemorrhage);乳铁蛋白(Lactoferrin);小鼠(Mice);小鼠, 肥胖(Mice, Obese);卒中(Stroke)

DOI 10.1016/j.redox.2022.102256

PMID 35131600

发布时间 2022-03-11

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