A computational comparative analysis of the binding mechanism of molnupiravir's active metabolite to RNA-dependent RNA polymerase of wild-type and Delta subvariant AY.4 of SARS-CoV-2.

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作者： Ismail,Celik ^[1] ; Trina E,Tallei ^[2]

作者单位： Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey. ^[1] Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, North Sulawesi, Indonesia. ^[2]

关键词 COVID-19 Delta subvariant AY.4 RNA-dependent RNA polymerase SARS-CoV-2 binding mechanism computational analysis molnupiravir triphosphate

主题词动物(Animals);抗病毒药(Antiviral Agents);胞苷(Cytidine);人类(Humans);羟胺类(Hydroxylamines);哺乳动物(Mammals);RNA, 病毒(RNA, Viral)

DOI 10.1002/jcb.30226

PMID 35132671

发布时间 2022-12-07

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