Impacts of the STING-IFNAR1-STAT1-IRF1 pathway on the cellular immune reaction induced by fractionated irradiation.

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作者： Junyan,Du ^[1] ; Shun-Ichiro,Kageyama ^[2] ; Riu,Yamashita ^[3] ; Hidenari,Hirata ^[4] ; Yumi,Hakozaki ^[1] ; Masayuki,Okumura ^[3] ; Atsushi,Motegi ^[4] ; Hidehiro,Hojo ^[4] ; Masaki,Nakamura ^[3] ; Yasuhiro,Hirano ^[3] ; Hironori,Sunakawa ^[3] ; Tatsunori,Minamide ^[3] ; Daisuke,Kotani ^[3] ; Kosuke,Tanaka ^[5] ; Tomonori,Yano ^[5] ; Takashi,Kojima ^[6] ; Akihiro,Ohashi ^[7] ; Katsuya,Tsuchihara ^[5] ; Tetsuo,Akimoto ^[6]

作者单位： Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan. ^[1] Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan. ^[2] Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Chiba, Japan. ^[3] Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, Japan. ^[4] Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan. ^[5] Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan. ^[6] Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan. ^[7]

关键词 cGAS-STING esophageal cancer fractionated irradiation immune checkpoint immune response