Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages.

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第一作者： Christopher,Hoyle

第一单位： Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Manchester, UK.;Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.;The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.

作者： Christopher,Hoyle ^[1] ; Jack P,Green ^[1] ; Stuart M,Allan ^[1] ; David,Brough ^[1] ; Eloise,Lemarchand ^[2]

作者单位： Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Manchester, UK.;Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.;The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK. ^[1] Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.;INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, Institut Blood and Brain @ Caen-Normandie (BB@C), Normandie University, Caen, France. ^[2]

关键词 NLRP3 fumarate inflammasome interleukin itaconate