Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages.

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第一作者： Hanieh,Moradian

第一单位： Institute of Active Polymers, Helmholtz-Zentrum Hereon, Kantstr. 55, 14513 Teltow, Germany.

作者： Hanieh,Moradian ^[1] ; Toralf,Roch ^[2] ; Larissa,Anthofer ^[3] ; Andreas,Lendlein ^[4] ; Manfred,Gossen ^[5]

作者单位： Institute of Active Polymers, Helmholtz-Zentrum Hereon, Kantstr. 55, 14513 Teltow, Germany. ^[1] Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Föhrerstr. 15, 13353 Berlin, Germany. ^[2] Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam, Germany. ^[3] Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Charitéplatz 1, 10117 Berlin, Germany. ^[4] Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Center for Advanced Therapies, Augustenburger Platz 1, 13353 Berlin, Germany. ^[5] Center for Translational Medicine, Immunology, and Transplantation, Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Hölkeskampring 40, 44625 Herne, Germany. ^[6]

关键词 IVT-mRNA modification antiviral response cap structure in vitro transcription (IVT)innate immune response mRNA chemistry macrophage activation proinflammatory response transfection

DOI 10.1016/j.omtn.2022.01.004

PMID 35141046

发布时间 2022-02-11

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Molecular therapy. Nucleic acids

2022年27卷

854-869页

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Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages.

Molecular therapy. Nucleic acids

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Molecular therapy. Nucleic acids

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Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages.

Molecular therapy. Nucleic acids

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Molecular therapy. Nucleic acids

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