Bex1 is essential for ciliogenesis and harbours biomolecular condensate-forming capacity.

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第一作者： Emi,Hibino

第一单位： Molecular Neuroscience Research Centre (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.;Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.

作者： Emi,Hibino ^[1] ; Yusuke,Ichiyama ^[2] ; Atsushi,Tsukamura ^[3] ; Yosuke,Senju ^[4] ; Takao,Morimune ^[3] ; Masahito,Ohji ^[2] ; Yoshihiro,Maruo ^[5] ; Masaki,Nishimura ^[6] ; Masaki,Mori ^[7]

作者单位： Molecular Neuroscience Research Centre (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.;Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. ^[1] Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan. ^[2] Molecular Neuroscience Research Centre (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.;Department of Paediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.;Department of Vascular Physiology, National Cerebral and Cardiovascular Centre Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan. ^[3] Research Institute for Interdisciplinary Science, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan. ^[4] Department of Paediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan. ^[5] Molecular Neuroscience Research Centre (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan. ^[6] Molecular Neuroscience Research Centre (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan. mori.masaki@ncvc.go.jp.;Department of Vascular Physiology, National Cerebral and Cardiovascular Centre Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan. mori.masaki@ncvc.go.jp. ^[7]

关键词 Bex1 Intrinsically disordered protein (IDP)Juvenility-associated genes (JAGs)Primary cilia Tubulin polymerization

主题词动物(Animals);纤毛(Cilia);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);微管(Microtubules);神经组织蛋白质类(Nerve Tissue Proteins);微管蛋白(Tubulin)

DOI 10.1186/s12915-022-01246-x

PMID 35144600

发布时间 2022-05-31

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