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Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy.

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第一作者: Hui,Ye
第一单位: Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.;12 de Octubre Health Research Institute (imas12), 28007, Madrid, Spain.;Department of Anesthesiology, ZhongDa Hospital Southeast University, 210009, Nanjing, China.
作者单位: Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.;12 de Octubre Health Research Institute (imas12), 28007, Madrid, Spain.;Department of Anesthesiology, ZhongDa Hospital Southeast University, 210009, Nanjing, China. [1] Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.;12 de Octubre Health Research Institute (imas12), 28007, Madrid, Spain.;Department of General Surgery, Wuxi Xishan People's hospital, 214105, Wuxi, China.;Department of Hepatic-Biliary-Pancreatic Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical school, 210000, Nanjing, China. [2] Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain. [3] Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.;12 de Octubre Health Research Institute (imas12), 28007, Madrid, Spain. [4] Departmento de Medicina Clínica, Universidad Miguel Hernández, 03550, San Juan de Alicante, Spain.;Instituto ISABIAL-FISABIO, Hospital General Universitario de Alicante, 03010, Alicante, Spain.;Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain. [5] Institute for Bioengineering (IBioE), Human Tissue Engineering, Faraday Building, The University of Edinburgh, EH9 3DW, Edinburgh, Scotland, UK. [6] Department of Cell Biology, Complutense University School of Medicine, 28040, Madrid, Spain. [7] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.;Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, 28007, Madrid, Spain.;Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007, Madrid, Spain. [8] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.;Hepatology Program, CIMA, University of Navarra, 31008, Pamplona, Spain.;Instituto de Investigaciones Sanitarias de Navarra IdiSNA, 31008, Pamplona, Spain. [9] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.;Unidad de Gestión Clínica de Digestivo, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, 29010, Málaga, Spain. [10] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.;Liver Disease Laboratory and Liver Metabolism Laboratory, CIC bioGUNE, CIBERehd, Bizkaia Science and Technology Park, 48160, Derio, Bizkaia, Spain. [11] The Liver Unit, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, NE7 DN, Newcastle upon Tyne, UK.;Newcastle University Translational and Clinical Research Institute, The Medical School, Newcastle University, NE7 DN, Newcastle upon Tyne, UK. [12] Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women´s Hospital, Harvard Medical School, Boston, and Harvard Digestive Diseases Center, 02115, Boston, MA, USA. [13] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.;Liver Vascular Biology Research Group, IDIBAPS, 08036, Barcelona, Spain.;Hepatology, Department of Biomedical Research, University of Bern, cH-3008, Bern, Switzerland. [14] Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.;Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.;Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007, Madrid, Spain.;Department of Internal Medicine III, University Hospital RWTH Aachen, 52074, Aachen, Germany. [15] Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain. fcubero@ucm.es.;Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain. fcubero@ucm.es.;Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007, Madrid, Spain. fcubero@ucm.es. [16]
DOI 10.1038/s41419-022-04580-8
PMID 35145060
发布时间 2024-02-10
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