Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation.

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作者： Francisco,Fueyo-González ^[1] ; Mitchell,McGinty ^[2] ; Mehek,Ningoo ^[1] ; Lisa,Anderson ^[1] ; Chiara,Cantarelli ^[3] ; Andrea Angeletti ^[4] ; Markus,Demir ^[5] ; Inés,Llaudó ^[1] ; Carolina,Purroy ^[6] ; Nada,Marjanovic ^[7] ; David,Heja ^[1] ; Stuart C,Sealfon ^[7] ; Peter S,Heeger ^[1] ; Paolo,Cravedi ^[1] ; Miguel,Fribourg ^[8]

作者单位： Division of Nephrology, Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Immunology Institute Icahn School of Medicine at Mount Sinai, New York City, NY, USA. ^[1] Carter Immunology Center, University of Virginia, Charlottesville, VA 22903, USA. ^[2] UO Nefrologia, Azienda Ospedaliero-Universitaria Parma, Parma, Italy. ^[3] Division of Nephrology, Dialysis, Transplantation, IRCCS Giannina Gaslini, Genoa, Italy. ^[4] Department of Anesthesiology, University of Cologne, Cologne, Germany. ^[5] Department of Nephrology, Complejo Hospitalario de Navarra, Navarra, Spain. ^[6] Immunology Institute Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. ^[7] Division of Nephrology, Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Immunology Institute Icahn School of Medicine at Mount Sinai, New York City, NY, USA. Electronic address: miguel.fribourg@mssm.edu. ^[8]

关键词 CTLA-4 Ig Foxp3 acetylation interferon-beta regulatory T?cells transplant