A simple quinoline salt derivative is active in vitro against Plasmodiumfalciparum asexual blood stages and inhibits the development of cerebral malaria in murine model.

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第一作者： Jessica Correa,Bezerra Bellei

第一单位： Research Center Parasitology. Departament of Parasitology, Microbiology and Immunology. Federal University of Juiz de Fora, Juiz de Fora/MG 36.036-900, Brazil.

作者： Jessica Correa,Bezerra Bellei ^[1] ; Nícolas,Glanzmann ^[2] ; Bárbara Albuquerque,Carpinter ^[1] ; Daniela Chaves,Renhe ^[1] ; Carolina Brandi,Marques ^[1] ; Marina Rocha,Azevedo ^[1] ; Livia Maria,Barreto ^[1] ; Vinicius Novaes,Rocha ^[3] ; Isabelle,Karine da Costa Nunes ^[4] ; Henrique Marcelo,Gualberto Pereira ^[4] ; Elaine Soares,Coimbra ^[1] ; Eduardo Antônio,Ferraz Coelho ^[5] ; Adilson,David da Silva ^[2] ; Fernando,de Pilla Varotti ^[6] ; Kézia Katiani,Gorza Scopel ^[7]

作者单位： Research Center Parasitology. Departament of Parasitology, Microbiology and Immunology. Federal University of Juiz de Fora, Juiz de Fora/MG 36.036-900, Brazil. ^[1] Department of Chemistry, Institute of Exact Sciences, Federal University of Juiz de Fora, Juiz de Fora/MG 36.036-900, Brazil. ^[2] Research Center of Pathology and Veterinary Histology. Departament of Veterinary Medicine /Federal University of Juiz de Fora, Juiz de Fora/MG 36.036-900, Brazil. ^[3] Technological Development Support Laboratory, Chemistry Hub, Federal University of Rio de Janeiro, Rio de Janeiro/RJ 21.941-598, Brazil. ^[4] Postgraduation Program in Health Sciences, Infectology and Tropical Medicine, Faculty of Medicine, Federal University of Minas Gerais, Av. Alfredo Balena, 190, 30130-100, Belo Horizonte, Minas Gerais, Brazil. ^[5] Research Center on Biological Chemistry (NQBio)/Federal University of São João Del Rei, Divinópolis, MG, Brazil. Electronic address: varotti@ufsj.edu.br. ^[6] Research Center Parasitology. Departament of Parasitology, Microbiology and Immunology. Federal University of Juiz de Fora, Juiz de Fora/MG 36.036-900, Brazil. Electronic address: keziagscopel@gmail.com. ^[7]

关键词 Cerebral malaria Malaria Plasmodium falciparum Quinoline derivative