Phase I trial of ATM inhibitor M3541 in combination with palliative radiotherapy in patients with solid tumors.

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作者： Saiama N,Waqar ; Clifford,Robinson ; Anthony J,Olszanski ; Alexander,Spira ; Melissa,Hackmaster ; Luisa,Lucas ; Laura,Sponton ; Hulin,Jin ; Ursula,Hering ; Damien,Cronier ; Marianna,Grinberg ; Annick,Seithel-Keuth ; Ivan,Diaz-Padilla ; Jordan,Berlin

关键词 ATM inhibitor DNA damage response DNA repair M3541 Palliative radiotherapy Solid tumor

主题词共济失调性毛细血管扩张(Ataxia Telangiectasia);贝叶斯定理(Bayes Theorem);剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);最大耐受剂量(Maximum Tolerated Dose);肿瘤(Neoplasms);蛋白激酶抑制剂(Protein Kinase Inhibitors)

DOI 10.1007/s10637-022-01216-8

PMID 35150356

发布时间 2024-08-27

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