Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation.

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作者： Christopher W,Wasson ^[1] ; Begoña,Caballero-Ruiz ^[2] ; Justin,Gillespie ^[3] ; Emma,Derrett-Smith ^[1] ; Jamel,Mankouri ^[4] ; Christopher P,Denton ^[2] ; Gianluca,Canettieri ^[4] ; Natalia A,Riobo-Del Galdo ^[3] ; Francesco,Del Galdo ^[2]

作者单位： Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS29JT, UK. ^[1] School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS29JT, UK. ^[2] Department of Molecular Medicine, Sapienza University of Rome, 00196 Rome, Italy. ^[3] Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London NW32PF, UK. ^[4] Leeds Institute of Medical Research, Faculty of Medicine and Health, University of Leeds, Leeds LS29JT, UK. ^[5] Scleroderma Programme, NIHR Leeds Musculoskeletal Biomedical Research Centre, Leeds LS29JT, UK. ^[6]

关键词 CLIC4 Ion channels Scleroderma fibrosis morphogens

主题词氯化物通道(Chloride Channels);成纤维细胞(Fibroblasts);纤维化(Fibrosis);猬蛋白质类(Hedgehog Proteins);人类(Humans);核蛋白质类(Nuclear Proteins);转化生长因子β(Transforming Growth Factor beta);增量调节(Up-Regulation);β连环素(beta Catenin)

DOI 10.3390/cells11030530

PMID 35159339

发布时间 2022-05-31

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2022年11卷3期

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Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation.

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Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation.

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