Deep Resequencing of 9 Candidate Genes Identifies a Role for ARAP1 and IGF2BP2 in Modulating Insulin Secretion Adjusted for Insulin Resistance in Obese Southern Europeans.

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作者： Diego,Bailetti ^[1] ; Federica,Sentinelli ^[1] ; Sabrina,Prudente ^[2] ; Flavia Agata,Cimini ^[3] ; Ilaria,Barchetta ^[2] ; Maria,Totaro ^[2] ; Alessia,Di Costanzo ^[1] ; Arcangelo,Barbonetti ^[4] ; Frida,Leonetti ^[1] ; Maria Gisella,Cavallo ^[5] ; Marco Giorgio,Baroni ^[2]

作者单位： Department of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy. ^[1] Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy. ^[2] Research Unit of Metabolic and Cardiovascular Diseases, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy. ^[3] Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. ^[4] Diabetes Unit, Department of Medical-Surgical Sciences and Biotechnologies, Santa Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy. ^[5] Neuroendocrinology and Metabolic Diseases, IRCCS Neuromed, 86077 Pozzilli, Italy. ^[6]

关键词 diabetes disposition index extremes insulin resistance insulin secretion next-generation sequencing obesity targeted resequencing