Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells.

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第一作者： Lukas,Seebauer

第一单位： Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander Universität, Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

作者： Lukas,Seebauer ^[1] ; Yanni,Schneider ^[1] ; Alice,Drobny ^[1] ; Sonja,Plötz ^[1] ; Tomas,Koudelka ^[2] ; Andreas,Tholey ^[2] ; Iryna,Prots ^[3] ; Beate,Winner ^[4] ; Friederike,Zunke ^[1] ; Jürgen,Winkler ^[5] ; Wei,Xiang ^[1]

作者单位： Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander Universität, Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany. ^[1] Systematic Proteome Research & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, 24105 Kiel, Germany. ^[2] Department of Stem Cell Biology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany. ^[3] Department of Stem Cell Biology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.;Center of Rare Diseases Erlangen (ZSEER), University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany. ^[4] Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander Universität, Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.;Center of Rare Diseases Erlangen (ZSEER), University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany. ^[5]

关键词 Parkinson’s disease SNCA duplication alpha-synuclein iPSC microtubule neurite neurodegeneration

主题词人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);微管(Microtubules);神经突(Neurites);帕金森病(Parkinson Disease);微管蛋白(Tubulin);α突触核蛋白(alpha-Synuclein)

DOI 10.3390/ijms23031812

PMID 35163733

发布时间 2024-08-22

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