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首页> Molecules (Basel, Switzerland)> In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment.

In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment.

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作者： Halilibrahim,Ciftci ^[1] ; Belgin,Sever ^[2] ; Firdevs,Ocak ^[3] ; Nilüfer,Bayrak ^[2] ; Mahmut,Yıldız ^[4] ; Hatice,Yıldırım ^[5] ; Hasan,DeMirci ^[6] ; Hiroshi,Tateishi ^[7] ; Masami,Otsuka ^[6] ; Mikako,Fujita ^[3] ; Amaç Fatih,TuYuN ^[2]

作者单位： Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan. ^[1] Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan. ^[2] Department of Molecular Biology and Genetics, Koc University, Istanbul 34450, Turkey. ^[3] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey. ^[4] Faculty of Medicine, Kocaeli University, Kocaeli 41001, Turkey. ^[5] Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul 34320, Turkey. ^[6] Chemistry Department, Gebze Technical University, Kocaeli 41400, Turkey. ^[7] Department of Chemistry, Faculty of Science, Istanbul University, Istanbul 34126, Turkey. ^[8]

关键词 DNA cleavage apoptosis colorectal cancer cytotoxicity molecular docking pharmacokinetic properties plastoquinones

主题词抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);结直肠肿瘤(Colorectal Neoplasms);计算机模拟(Computer Simulation);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);分子结构(Molecular Structure);质体醌(Plastoquinone);构效关系(Structure-Activity Relationship)

DOI 10.3390/molecules27030693

PMID 35163957

发布时间 2022-02-22

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Molecules (Basel, Switzerland)

Molecules (Basel, Switzerland)

2022年27卷3期

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