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T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.

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作者单位: Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.;Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Neuroelectronic Systems, Medical Center-University of Freiburg, Freiburg, Germany.;Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Freiburg, Germany. [1] Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.;Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany. [2] Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.;Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, University of Freiburg, Freiburg, Germany. [3] Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Department of Medicine I, Medical Center-University of Freiburg, Freiburg, Germany. [4] Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Freiburg, Germany.;Comprehensive Cancer Center Freiburg (CCCF), Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.;German Cancer Consortium (DKTK), partner site Freiburg, Freiburg, Germany. [5] Department of Neurology and Brain Tumor Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland. [6] Department of Neurosurgery, RWTH University of Aachen, Aachen, Germany.;Neurosurgical Artificial Intelligence Laboratory Aachen (NAILA), Department of Neurosurgery, RWTH University of Aachen, Aachen, Germany. [7] Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany. [8] Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Department of Anesthesiology and Critical Care Medicine, Medical Center-University of Freiburg, Freiburg, Germany. [9] Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, University of Freiburg, Freiburg, Germany. [10] Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Neuroelectronic Systems, Medical Center-University of Freiburg, Freiburg, Germany. [11] Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Institute of Neuropathology, Medical Center-University of Freiburg, Freiburg, Germany. [12] Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Institute of Neuropathology, Medical Center-University of Freiburg, Freiburg, Germany.;Signalling Research Centre BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.;Center for NeuroModulation (NeuroModul), University of Freiburg, Freiburg, Germany. [13] Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Center for NeuroModulation (NeuroModul), University of Freiburg, Freiburg, Germany. [14] Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Signalling Research Centre BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.;Department of Medicine II: Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, Medical Center- University of Freiburg, Freiburg, Germany. [15] Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany. dieter.henrik.heiland@uniklinik-freiburg.de.;Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany. dieter.henrik.heiland@uniklinik-freiburg.de.;Faculty of Medicine, University of Freiburg, Freiburg, Germany. dieter.henrik.heiland@uniklinik-freiburg.de.;Comprehensive Cancer Center Freiburg (CCCF), Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. dieter.henrik.heiland@uniklinik-freiburg.de.;German Cancer Consortium (DKTK), partner site Freiburg, Freiburg, Germany. dieter.henrik.heiland@uniklinik-freiburg.de. [16]
DOI 10.1038/s41467-022-28523-1
PMID 35177622
发布时间 2024-08-24
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