TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection.

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第一作者： Renée M,van der Sluis

第一单位： Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark.

作者： Renée M,van der Sluis ^[1] ; Lamin B,Cham ^[2] ; Albert,Gris-Oliver ^[3] ; Kristine R,Gammelgaard ^[4] ; Jesper G,Pedersen ^[2] ; Manja,Idorn ^[2] ; Ulvi,Ahmadov ^[2] ; Sabina Sanches,Hernandez ^[2] ; Ena,Cémalovic ^[2] ; Stine H,Godsk ^[2] ; Jacob,Thyrsted ^[2] ; Jesper D,Gunst ^[5] ; Silke D,Nielsen ^[6] ; Janni J,Jørgensen ^[2] ; Tobias Wang,Bjerg ^[2] ; Anders,Laustsen ^[3] ; Line S,Reinert ^[2] ; David,Olagnier ^[2] ; Rasmus O,Bak ^[2] ; Mads,Kjolby ^[2] ; Christian K,Holm ^[2] ; Martin,Tolstrup ^[2] ; Søren R,Paludan ^[1] ; Lasse S,Kristensen ^[2] ; Ole S,Søgaard ^[7] ; Martin R,Jakobsen ^[8]

作者单位： Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark. ^[1] Department of Biomedicine, Aarhus University, Aarhus, Denmark. ^[2] Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark. ^[3] Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. ^[4] Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. ^[5] Clinic of Medicine, St. Olav's University Hospital, Trondheim, Norway. ^[6] DANDRITE, Department of Biomedicine, Aarhus University, Aarhus, Denmark. ^[7] Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark. ^[8]

关键词 SARS-CoV-2 TLR7 innate immune sensing neuropilin-1 pDC