CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587.

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作者： Kun,Lin ^[1] ; Shang-Hang,Shen ^[2] ; Feng,Lu ^[3] ; Pengfeng,Zheng ^[1] ; Shizhong,Wu ^[2] ; Jingwei,Liao ^[1] ; Xiaohang,Jiang ^[2] ; Guangming,Zeng ^[1] ; De,Wei ^[2]

作者单位： Department of Neurosurgery, Fujian Provincial Hospital South Branch, 516 Jinrong South Road, Fuzhou, 350001, China. ^[1] Department of Neurosurgery, Shengli Clinical Medical College of Fujian Medical University, 516 Jinrong South Road, Fuzhou, 350001, China. ^[2] Department of Neurosurgery, The First Affiliated Hospital of Xiamen University, Medical College of Xiamen University, Xiamen, 361003, China. ^[3] Department of Neurosurgery, Fujian Provincial Hospital South Branch, 516 Jinrong South Road, Fuzhou, 350001, China. weidele@fjmu.edu.cn. ^[4] Department of Neurosurgery, Fujian Provincial Hospital, 134 East Street, Fuzhou, 350001, China. weidele@fjmu.edu.cn. ^[5] Department of Neurosurgery, Shengli Clinical Medical College of Fujian Medical University, 134 East Street, Fuzhou, 350001, China. weidele@fjmu.edu.cn. ^[6]

关键词 CRISPR screening E3 ubiquitin ligases Glioblastoma Promoter hypermethylation Ring Finger Protein 185 miR-587

主题词脑肿瘤(Brain Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);胶质母细胞瘤(Glioblastoma);人类(Humans);微RNAs(MicroRNAs);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.1186/s12967-022-03284-z

PMID 35183197

发布时间 2022-05-31

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