首页> Journal of molecular biology> Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.

导出 OA

翻译打印收藏纠错

第一作者： Jacqueto,Zephyr

第一单位： Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, United States.

作者： Jacqueto,Zephyr ^[1] ; Desaboini,Nageswara Rao ^[1] ; Sang V,Vo ^[1] ; Mina,Henes ^[1] ; Klajdi,Kosovrasti ^[1] ; Ashley N,Matthew ^[1] ; Adam K,Hedger ^[1] ; Jennifer,Timm ^[1] ; Elise T,Chan ^[1] ; Akbar,Ali ^[1] ; Nese,Kurt Yilmaz ^[1] ; Celia A,Schiffer ^[2]

作者单位： Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, United States. ^[1] Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, United States. Electronic address: Celia.Schiffer@umassmed.edu. ^[2]

关键词 X-ray crystallography medicinal chemistry protease inhibitors structural biology structure-based drug design

医学主题词氨基异丁酸类(Aminoisobutyric Acids);环丙烷类(Cyclopropanes);药物设计(Drug Design);抗药性, 病毒(Drug Resistance, Viral);氟(Fluorine);卤化作用(Halogenation);肝炎病毒属(Hepacivirus);人类(Humans);内酰胺类, 大环(Lactams, Macrocyclic);亮氨酸(Leucine);脯氨酸(Proline);喹恶啉类(Quinoxalines);磺胺类(Sulfonamides)

DOI 10.1016/j.jmb.2022.167503

PMID 35183560

发布时间 2023-05-16

基金项目

F31 GM119345/GM/NIGMS NIH HHS/United States F31 GM131635/GM/NIGMS NIH HHS/United States R01 AI085051/AI/NIAID NIH HHS/United States R01 GM135919/GM/NIGMS NIH HHS/United States

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交