首页> Oncoimmunology> An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation.

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation.

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第一作者： Alexander,Muik

第一单位： BioNTech SE, Mainz, Germany.

作者： Alexander,Muik ^[1] ; Isil,Altintas ^[2] ; Friederike,Gieseke ^[1] ; Kristina B,Schoedel ^[1] ; Saskia M,Burm ^[2] ; Aras,Toker ^[1] ; Theodora W,Salcedo ^[3] ; Dennis,Verzijl ^[4] ; David,Eisel ^[1] ; Christian,Grunwitz ^[1] ; Lena M,Kranz ^[1] ; Mathias,Vormehr ^[1] ; David P E,Satijn ^[4] ; Mustafa,Diken ^[1] ; Sebastian,Kreiter ^[1] ; Kate,Sasser ^[3] ; Tahamtan,Ahmadi ^[4] ; Özlem,Türeci ^[1] ; Esther C W,Breij ^[2] ; Maria,Jure-Kunkel ^[3] ; Ugur,Sahin ^[5]

作者单位： BioNTech SE, Mainz, Germany. ^[1] Genmab, Utrecht, The Netherlands. ^[2] Genmab, Princeton, NJ, USA. ^[3] BioNTech SE, Mainz, Germany.;Genmab, Utrecht, The Netherlands.;Genmab, Princeton, NJ, USA.;TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany. ^[4] BioNTech SE, Mainz, Germany.;TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany. ^[5]

关键词 4-1BB PD-L1 T cells bispecific antibody checkpoint immunotherapy

医学主题词动物(Animals);抗体, 双特异性(Antibodies, Bispecific);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);人类(Humans);小鼠(Mice);肿瘤(Neoplasms);肿瘤微环境(Tumor Microenvironment)

DOI 10.1080/2162402X.2022.2030135

PMID 35186440

发布时间 2022-04-08

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准确一般字义偏差语意偏离译文作用小提交