Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation.

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作者： Hui-Lu,Zhang ^[1] ; Ping,Chen ^[1] ; He-Xin,Yan ^[2] ; Gong-Bo,Fu ^[3] ; Fei-Fei,Luo ^[1] ; Jun,Zhang ^[1] ; Shi-Min,Zhao ^[1] ; Bo,Zhai ^[2] ; Jiang-Hong,Yu ^[1] ; Lin,Chen ^[1] ; Hao-Shu,Cui ^[1] ; Jian,Chen ^[1] ; Shuai,Huang ^[2] ; Jun,Zeng ^[4] ; Wei,Xu ^[1] ; Hong-Yang,Wang ^[5] ; Jie,Liu ^[6]

作者单位： Department of Digestive Diseases of Huashan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200040, China. ^[1] Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200120, China. ^[2] Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, 210093, China. ^[3] Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. ^[4] Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200433, China. ^[5] National Center for Liver Cancer, Shanghai, 200433, China. ^[6]

关键词 HDAC3 Rictor/mTORC2 glutamine starvation glutamine synthetase tumor initiating cells

主题词细胞系(Cell Line);谷氨酰胺连接酶(Glutamate-Ammonia Ligase);谷氨酰胺(Glutamine);组蛋白脱乙酰基酶类(Histone Deacetylases);人类(Humans);肝肿瘤(Liver Neoplasms);转录因子(Transcription Factors)

DOI 10.1002/advs.202103887

PMID 35187863

发布时间 2022-07-25

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2022年9卷20期

e2103887页

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Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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